• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer
  • Locations:
  • Canyon
  • Center
  • College Station
  • Gonzales
  • TVMDL Career Center
  • Contact Us

Texas A&M Veterinary Medical Diagnostic Laboratory

Apple App

download on the Apple App Store
download the app on Google Play

Search

Translate:

  • Find a Form
  • Deliver a Sample
    • Specimen Collection Information
    • Packaging Samples for Shipment
    • Drop Off a Sample
    • Cremation
    • Order Supplies
  • Client Portal
    • Get Test Results
    • SVA Portal
    • Pay a Bill
  • Become a Client
  • Resources
    • TVMDL Bovine Testing Guidance and Reference Material
    • Diagnostic Plans
      • Bovine Syndromic Diagnostic Plans
      • Equine Syndromic Diagnostic Plans
      • Small Ruminant Syndromic Diagnostic Plans
      • Small Animal Syndromic Diagnostic Plans
    • Education Library
    • Case Study Library
    • Electronic Reporting: QR Coding Process
    • CoreOne Resources
  • About Us
    • Locations and Hours
    • Agency Leadership
    • Speaker’s Bureau
    • Texas Pullorum-Typhoid Program
    • TVMDL Mobile app
    • Contact Us
  • Locations
    • College Station Laboratory
    • Canyon Laboratory
    • Center Laboratory
    • Gonzales Laboratory
  • Contact Us

Sudden deaths in rabbit breeding colony attributed to Clostridium septicum

December 21, 2017 by Mallory Pfeifer

Sudden deaths in rabbit breeding colony attributed to Clostridium septicum
Written by Dr. Barbara Lewis, Veterinary Pathologist

With over 800,000 tests run annually, TVMDL encounters many challenging cases. Our case study series will highlight these interesting cases to increase awareness among veterinary and diagnostic communities.

A rabbit breeding colony experienced multiple sudden deaths in a barn that typically had few death losses.  The rabbits were noted grossly to have hemorrhage in the cecum and colon.  Tissues from a 20-month-old female Flemish Giant rabbit were submitted for histopathology and bacterial culture.  Histologically the rabbit had a marked, diffuse necrotizing and hemorrhagic typhiltis with intralesional Gram positive bacilli, mild heterophilic colitis and focal acute hepatic necrosis.  Clostridium septicum was cultured from swabs of the cecum and colon.

Enteritis complex with signs ranging from soft stool and diarrhea to enterotoxemia, sepsis and death is one of the most common diseases in rabbits.  The disease is typically multifactorial involving pathogenic bacteria and intrinsic and extrinsic factors that allow them to proliferate.  Clostridium spiroforme, enteropathogenic E. coli, Lawsonia intracellularis, Clostridium piliforme, Salomnella and Pseudomonassp. are most often implicated.

Clostridium septicum is the common cause of malignant edema (gas gangrene) of animals and the cause of braxy (necrotizing abomasitis) in sheep in Britain.  It is a ubiquitous soil-borne organism and a common inhabitant of the animal environment and digestive tract of large animals. A single case of necrotizing gastritis due to Cl. septicum in a rabbit was reported in 2014 from a research colony in California.  It appears that Cl. septicum is an uncommon, but possible, gastrointestinal pathogen of rabbits.

To learn more about this case, contact Dr. Barbara Lewis, Veterinary Pathologist, at the College Station lab. For more information about TVMDL, call 1.888.646.5623 or visit tvmdl.tamu.edu.

References:
JP Garcia, J Moore, P Loukopoulos, SS Diab, FA Uzal. Necrotizing gastritis associated with Clostridium septicum in a rabbit. Journal of Veterinary Diagnostic Investigation, Vol. 26(5) 669–673, 2014
OM Radostits, CC Gay, KW Hinchcliff, PD Constable, eds. Veterinary Medicine 10th ed., Elsevier Limited, 2007
KE Quesenberry, JW Carpenter, eds. Ferrets, Rabbits and Rodents Clinical Medicine and Surgery 3rd ed., Elsevier, 2012

Filed Under: Case Study Tagged With: companion, flemish giant, rabbit, TVMDL, veterinary

Primary Sidebar

Latest Case Studies

  • Neurologic Disease due to Bovine Herpesvirus-5 (BHV-5) Infection in a 3-week-old Charolais mix calf

    February 27, 2023

  • Rare case of ocular onchocerciasis in a dog from south Texas

    January 25, 2023

  • Cerebrospinal Nematodiasis (Visceral Larval Migrans) in Birds

    September 13, 2022

  • Spironucleosis (Hexamitiasis) in Quail

    August 9, 2022

  • Endocarditis in a White-Tailed Deer Caused by Trueperella pyogenes

    August 9, 2022

Footer

For Employees

  • Employee Email
  • TVMDL Rules & Procedures
  • TVMDL Career Center
  • Emergency Alert Systems
  • AgriLife People Directory
  • AgriLife Administrative Services
  • TAMUS Single Sign On
  • Facebook

State of Texas

  • Texas.gov Portal
  • Texas Veterans Portal
  • Statewide Search
  • Texas Homeland Security
  • Risk, Fraud, & Misconduct Hotline

Policies

  • Privacy and Security Policy
  • Accessibility Policy
  • Texas A&M AgriLife
  • Texas A&M Veterinary Medical Diagnostics Laboratory
  • Texas A&M Forest Service
  • Texas A&M AgriLife Extension Service
  • Texas A&M AgriLife Research

483 Agronomy Rd
College Station, TX 77843