Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL) Assistant Agency Director for Pathology Gabriel Gomez, DVM, PhD, DACVP is part of a team who recently published a journal article covering the ability for certain pathogens to subvert typical immune defenses. Gomez, along with colleagues at the Texas A&M College of Veterinary Medicine and Biomedical Sciences (CVMBS), specifically explored Brucella‘s ability to destabilize the typical phagocytosis and destruction of pathogens in lysosomes that contribute to immune defense through the activation of regulated IRE1α-dependent decay (RIDD) of mRNAs encoding BLOS1, a protein that promotes endosome-lysosome fusion. The article establishes BLOS1 as a novel immune defense factor whose activity is hijacked by diverse pathogens, such as Brucella.
Learn more about this study and access the article by visiting bioRxiv.